The existing ZigBee network routing algorithm has unbalanced energy consumption. To solve the problem, based on the tree routing algorithm and Ad-Hoc On-demand Distance Vector junior (AODVjr) algorithm, the ZigBee hybrid routing algorithm based on uneven clustering mechanism was proposed. The algorithm divided the network into several uneven logical clusters, the scale of cluster close to the coordinator was smaller, so the forwarding task could be reduced, and the energy consumption was balanced. Based on the clustering, the transmission was divided into transmission within the clusters and between the clusters. Transmission within the clusters used tree routing algorithm based on the neighbor table. While the transmission between the clusters used the AODVjr algorithm, because the tree routing algorithm based on the neighbor table was invalid, which could find out shorter path between two cluster head nodes, in the same time, only the cluster head nodes and gateway nodes could broadcast Route Request (RREQ) packet, which helped to reduce the redundant RREQ packets. The simulation results show that the proposed algorithm can effectively delay the time of the death node and prolong the network lifetime, thus improving the network performance.